Clinical Question Among patients at high risk for or with established cardiovascular disease
(ie, history of peripheral artery disease, stroke, or coronary artery disease without a coronary
stent), is the addition of clopidogrel to aspirin associated with lower risk of mortality and
cardiovascular events compared with aspirin alone? Bottom Line Clopidogrel plus aspirin is
associated with a reduced risk for myocardial infarction and ischemic stroke and an
increased risk for major bleeding compared with aspirin alone among patients at high risk …